Network medicine for disease module identification and drug repurposing with the NeDRex platform.

ABSTRACT: Traditional drug discovery faces a severe efficacy crisis. Repurposing of registered drugs provides an alternative with lower costs and faster drug development timelines. However, the data necessary for the identification of disease modules, i.e. pathways and sub-networks describing the mechanisms of complex diseases which contain potential drug targets, are scattered across independent databases. Moreover, existing studies are limited to predictions for specific diseases or non-translational algorithmic approaches. There is an unmet need for adaptable tools allowing biomedical researchers to employ network-based drug repurposing approaches for their individual use cases. We close this gap with NeDRex, an integrative and interactive platform for network-based drug repurposing and disease m

SUBMITTER: Sadegh S 

PROVIDER: S-EPMC8617287 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature