Resting-state functional heterogeneity of the right insula contributes to pain sensitivity.

ABSTRACT: Previous studies have described the structure and function of the insular cortex in terms of spatially continuous gradients. Here we assess how spatial features of insular resting state functional organization correspond to individual pain sensitivity. From a previous multicenter study, we included 107 healthy participants, who underwent resting state functional MRI scans, T1-weighted scans and quantitative sensory testing on the left forearm. Thermal and mechanical pain thresholds were determined. Connectopic mapping, a technique using non-linear representations of functional organization was employed to describe functional connectivity gradients in both insulae. Partial coefficients of determination were calculated between trend surface model parameters summarizing spatial features of gr

SUBMITTER: Vereb D 

PROVIDER: S-EPMC8617295 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature