Proteomic profiling identifies signatures associated with progression of precancerous gastric lesions and risk of early gastric cancer.

ABSTRACT:

Background

Molecular features underlining the multistage progression of gastric lesions and development of early gastric cancer (GC) are poorly understood, restricting the ability to GC prevention and management.

Methods

We portrayed proteomic landscape and explored proteomic signatures associated with progression of gastric lesions and risk of early GC. Tissue proteomic profiling was conducted for a total of 324 subjects. A case-control study was performed in the discovery stage (n=169) based on populations from Linqu, a known high-risk area for GC in China. We then conducted two-stage validation, including a cohort study from Linqu (n = 56), with prospective follow-up for progression of gastric lesions (280-473 days), and an independent case-control study from Beijing (n =

SUBMITTER: Li X 

PROVIDER: S-EPMC8617343 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature