Maternal cannabis use is associated with suppression of immune gene networks in placenta and increased anxiety phenotypes in offspring.

ABSTRACT: While cannabis is among the most used recreational drugs during pregnancy, the impact of maternal cannabis use (mCB) on fetal and child development remains unclear. Here, we assessed the effects of mCB on psychosocial and physiological measures in young children along with the potential relevance of the in utero environment reflected in the placental transcriptome. Children (∼3 to 6 y) were assessed for hair hormone levels, neurobehavioral traits on the Behavioral Assessment System for Children (BASC-2) survey, and heart rate variability (HRV) at rest and during auditory startle. For a subset of children with behavioral assessments, placental specimens collected at birth were processed for RNA sequencing. Hair hormone analysis revealed increased cortisol levels in mCB children. In addition

SUBMITTER: Rompala G 

PROVIDER: S-EPMC8617511 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature