PSD-95: An Effective Target for Stroke Therapy Using Neuroprotective Peptides.

ABSTRACT: Therapies for stroke have remained elusive in the past despite the great relevance of this pathology. However, recent results have provided strong evidence that postsynaptic density protein-95 (PSD-95) can be exploited as an efficient target for stroke neuroprotection by strategies able to counteract excitotoxicity, a major mechanism of neuronal death after ischemic stroke. This scaffold protein is key to the maintenance of a complex framework of protein interactions established at the postsynaptic density (PSD) of excitatory neurons, relevant to neuronal function and survival. Using cell penetrating peptides (CPPs) as therapeutic tools, two different approaches have been devised and advanced to different levels of clinical development. First, nerinetide (Phase 3) and AVLX-144 (Phase 1) we

SUBMITTER: Ugalde-Trivino L 

PROVIDER: S-EPMC8618101 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature