L-Menthol-Loadable Electrospun Fibers of PMVEMA Anhydride for Topical Administration.

ABSTRACT: Poly(methyl vinyl ether-alt-maleic anhydride) (PMVEMA) of 119 and 139 molecular weights (P119 and P139, respectively) were electrospun to evaluate the resulting fibers as a topical delivery vehicle for (L-)menthol. Thus, electrospinning parameters were optimized for the production of uniform bead-free fibers from 12% w/w PMVEMA (±2.3% w/w menthol) solutions, and their morphology and size were characterized by field emission scanning electron microscopy (FESEM). The fibers of P119 (F₁₁₉s) and P139 (F₁₃₉s) showed average diameter sizes of approximately 534 and 664 nm, respectively, when unloaded, and 837 and 1369 nm when loaded with menthol. The morphology of all types of fibers was cylindrical except for F₁₃₉s, which mostly

SUBMITTER: Mira A 

PROVIDER: S-EPMC8618103 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature