Metabolism of Daidzein and Genistein by Gut Bacteria of the Class Coriobacteriia.

ABSTRACT: The intake of isoflavones is presumed to be associated with health benefits in humans, but also potential adverse effects of isoflavones are controversially discussed. Isoflavones can be metabolized by gut bacteria leading to modulation of the bioactivity, such as estrogenic effects. Especially bacterial strains of the Eggerthellaceae, a well-known bacterial family of the human gut microbiota, are able to convert the isoflavone daidzein into equol. In addition, metabolization of genistein is also described for strains of the Eggerthellaceae. The aim of this study was to identify and investigate gut bacterial strains of the family Eggerthellaceae as well as the narrowly related family Coriobacteriaceae which are able to metabolize daidzein and genistein. This stu

SUBMITTER: Soukup ST 

PROVIDER: S-EPMC8618169 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature