Liquid Biopsy-Based Colorectal Cancer Screening via Surface Markers of Circulating Tumor Cells.

ABSTRACT: Colorectal cancer (CRC) is ranked second for cancer-related deaths worldwide with approximately half of the patients being diagnosed at the late stages. The untimely detection of CRC results in advancement to the metastatic stage and nearly 90% of cancer-related deaths. The early detection of CRC is crucial to decrease its overall incidence and mortality rates. The recent introduction of circulating tumor cells (CTCs) has enabled a less invasive sampling method from liquid biopsies, besides revealing key information toward CRC metastasis. The current gold standard for CTC identification is the CellSearch® system (Veridex). This first-generation instrumentation relies on a single cell surface marker (CSM) to capture and count CTCs. Detection of CTCs allows the identification of patients at

SUBMITTER: Tieng FYF 

PROVIDER: S-EPMC8618170 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature