Outpatient Nephrotoxic Medication Prescription after Pediatric Intensive Care Acute Kidney Injury.

ABSTRACT:

Background

Nephrotoxic medication (NTM) avoidance may prevent further kidney damage in children with acute kidney injury (AKI). We compared outpatient NTM prescriptions in children with or without AKI during pediatric intensive care (PICU) hospitalization. We hypothesize that children with AKI are prescribed NTMs at the same rate as those without it.

Methods

This was a retrospective administrative data study of children <18 years, admitted to two PICUs in Montreal, Canada, from 2003 to 2005, with ≥30 days of provincial drug coverage. We evaluated the presence of ≥3 outpatient NTM prescriptions during the first year and 5 years after PICU discharge.

Results

Of 970 children, 23% had PICU AKI. In the 1st-5th years after discharge, 18% AKI vs. 10% non-AKI and 13% AKI vs.

SUBMITTER: Lefebvre C 

PROVIDER: S-EPMC8618325 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature