Development and Characterization of Magnetic SARS-CoV-2 Peptide-Imprinted Polymers.

ABSTRACT: The development of new methods for the rapid, sensitive, and selective detection of SARS-CoV-2 is a key factor in overcoming the global pandemic that we have been facing for over a year. In this work, we focused on the preparation of magnetic molecularly imprinted polymers (MMIPs) based on the self-polymerization of dopamine at the surface of magnetic nanoparticles (MNPs). Instead of using the whole SARS-CoV-2 virion as a template, a peptide of the viral spike protein, which is present at the viral surface, was innovatively used for the imprinting step. Thus, problems associated with the infectious nature of the virus along with its potential instability when used as a template and under the polymerization conditions were avoided. Dopamine was selected as a functional monomer following a r

SUBMITTER: Fresco-Cala B 

PROVIDER: S-EPMC8618860 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature