Characterization of Biomarkers in Colorectal Cancer Liver Metastases as a Prognostic Tool.

ABSTRACT:

Background

Unfortunately, the majority of patients with colorectal cancer liver metastases (CRCLM) experience disease recurrence following hepatic surgery. The key challenge is therefore optimal patient selection, which currently relies on anatomical and clinical parameters. Exploring a potential molecular signature may be predictive for seeing a clinical benefit from CRCLM resection.

Methods

Consecutive patients who underwent CRCLM resection at our medical center between 2006 and 2016 were divided into cohorts of "good prognosis" (GP) or "poor prognosis" (PP) based on the time interval between their resection and disease recurrence. Proteomic analysis was performed on the surgical specimen and correlation analysis was carried out with demographics and clinical outcomes.

SUBMITTER: Michal S 

PROVIDER: S-EPMC8618941 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature