Laxative Effects of a Standardized Extract of Dendropanax morbiferus H. Leveille Leaves on Experimental Constipation in Rats.

ABSTRACT: Background and Objectives: This study aimed at investigating the laxative effects of a standardized aqueous extract of Dendropanax morbiferus H. Lév. on two different constipation rat models. Materials and Methods: Animal studies were conducted with low-fiber diet-induced and loperamide-induced constipation animal models, and isolated colons were used in ex vivo analysis to determine the changes in colonic motility caused by D. morbiferus H. Lév. leaf extract (DPL). Results: The results showed that DPL administration significantly improved certain reduced fecal parameters (number, weight, and water content of the stools) in a both low-fiber diet and loperamide-induced constipation models without adverse effects of diarrhea. The laxative effect of DPL was confirmed to improve the charcoal e

SUBMITTER: Na JR 

PROVIDER: S-EPMC8619072 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature