Structure-Activity Relationship of Graphene-Based Materials: Impact of the Surface Chemistry, Surface Specific Area and Lateral Size on Their In Vitro Toxicity.

ABSTRACT: Predictive toxicity and structure-activity relationships (SARs) are raising interest since the number of nanomaterials has become unmanageable to assess their toxicity with a classical case-by-case approach. Graphene-based materials (GBMs) are among the most promising nanomaterials of this decade and their application might lead to several innovations. However, their toxicity impact needs to be thoroughly assessed. In this regard, we conducted a study on 22 GBMs to investigate their potential SARs by performing a complete physicochemical characterization and in vitro toxicity assessment (on RAW264.7 cells). We used GBMs of variable lateral size (0.5-38 µm), specific surface area (SSA, 30-880 m²/g), and surface oxidation (2-17%). We observed that reduced graphene oxides (RGOs) were more rea

SUBMITTER: Achawi S 

PROVIDER: S-EPMC8619174 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature