Cardiac Cell Patterning on Customized Microelectrode Arrays for Electrophysiological Recordings.

ABSTRACT: Cardiomyocytes (CMs) and fibroblast cells are two essential elements for cardiac tissue structure and function. The interactions between them can alter cardiac electrophysiology and thus contribute to cardiac diseases, such as arrhythmogenesis. One possible explanation is that fibroblasts can directly affect cardiac electrophysiology through electrical coupling with CMs. Therefore, detecting the electrical activities in the CM-fibroblast network is vital for understanding the coupling dynamics among them. Current commercialized platforms for studying cardiac electrophysiology utilize planar microelectrode arrays (MEAs) to record the extracellular field potential (FP) in real-time, but the prearranged electrode configuration highly limits the measurement capabilities at specific locations.

SUBMITTER: Ji J 

PROVIDER: S-EPMC8619285 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature