Randomized Controlled Trial of Probiotic PS128 in Children with Tourette Syndrome.

ABSTRACT: Tourette syndrome results from a complex interaction between social-environmental factors, multiple genetic abnormalities, and neurotransmitter disturbances. This study is a double-blinded, randomized controlled trial using probiotics Lactobacillus plantarum PS128 as an intervention to examine if probiotics improve symptoms of children with Tourette syndrome. This study enrolled children aged 5 to 18 years old who fulfilled DSM-V diagnostic criteria for Tourette syndrome. Patients were assessed before initiating the trial, at one month, and at two months after randomization. The primary outcome was evaluated by Yale Global Tic Severity Scale (YGTSS), and the secondary outcome studied the possible comorbidities in these children. The results revealed no significant difference in impr

SUBMITTER: Wu CC 

PROVIDER: S-EPMC8619307 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature