Interaction between Non-Coding RNAs and Androgen Receptor with an Especial Focus on Prostate Cancer.

ABSTRACT: The androgen receptor (AR) is a member of the nuclear receptor superfamily and has three functional domains, namely the N-terminal, DNA binding, and C-terminal domain. The N-terminal domain harbors potent transactivation functions, whereas the C-terminal domain binds to androgens and antiandrogens used to treat prostate cancer. AR has genomic activity being DNA binding-dependent or through interaction with other DNA-bound transcription factors, as well as a number of non-genomic, non-canonical functions, such as the activation of the ERK, AKT, and MAPK pathways. A bulk of evidence indicates that non-coding RNAs have functional interactions with AR. This type of interaction is implicated in the pathogenesis of human malignancies, particularly prostate cancer. In the current review, we summa

SUBMITTER: Taheri M 

PROVIDER: S-EPMC8619311 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature