Nanostring-Based Identification of the Gene Expression Profile in Trigger Finger Samples.

ABSTRACT: Trigger finger is a common yet vastly understudied fibroproliferative hand pathology, severely affecting patients' quality of life. Consistent trauma due to inadequate positioning within the afflicted finger's tendon/pulley system leads to cellular dysregulation and eventual fibrosis. While the genetic characteristics of the fibrotic tissue in the trigger finger have been studied, the pathways that govern the initiation and propagation of fibrosis are still unknown. The complete gene expression profile of the trigger finger has never been explored. Our study has used the Nanostring nCounter gene expression assay to investigate the molecular signaling involved in trigger finger pathogenesis. We collected samples from patients undergoing trigger finger (n = 4) release surgery and comp

SUBMITTER: Kolhe R 

PROVIDER: S-EPMC8619339 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature