Ultrasound-Based Method for the Identification of Novel MicroRNA Biomarkers in Prostate Cancer.

ABSTRACT: The detection of circulating microRNA (miRNA)-based biomarkers represents an innovative, non-invasive method for the early detection of cancer. However, the low concentration of miRNAs released in body fluids and the difficult identification of the tumor site have limited their clinical use as effective cancer biomarkers. To evaluate if ultrasound treatment could amplify the release of extracellular cancer biomarkers, we treated a panel of prostate cancer (PCa) cell lines with an ultrasound-based prototype and profiled the release of miRNAs in the extracellular space, with the aim of identifying novel miRNA-based biomarkers that could be used for PCa diagnosis and the monitoring of tumor evolution. We provide evidence that US-mediated sonoporation amplifies the release of miRNAs from both

SUBMITTER: Cornice J 

PROVIDER: S-EPMC8619582 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature