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Briarane-Related Diterpenoids from Octocoral Briareum stechei.

ABSTRACT: A known polyoxygenated briarane, briaexcavatolide P (1), was isolated from a Formosan octocoral Briareum stechei. Moreover, the same species B. stechei, collected from Okinawan waters, yielded three chlorine-containing briaranes, including two new compounds, briastecholides B (2) and C (3) as well as a known analogue, briarenol R (4). The structures of 1-4 were established using spectroscopic methods. In addition, briarane 1 demonstrated anti-inflammatory activity in lipo-polysaccharide-induced RAW 264.7 mouse macrophage cells by suppressing the expression of inducible nitric oxide synthase (iNOS) protein.

SUBMITTER: Huynh TH

PROVIDER: S-EPMC8619598 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature

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Briarane-Related Diterpenoids from Octocoral Briareum stechei.

Huynh Thanh-Hao TH Neoh Choo-Aun CA Tsai Yu-Chi YC Yao Zhi-Kang ZK Zheng Li-Guo LG Huang Pin-Chang PC Wen Zhi-Hong ZH Chen Jih-Jung JJ Wu Yu-Jen YJ Sung Ping-Jyun PJ

Molecules (Basel, Switzerland) 20211113 22

A known polyoxygenated briarane, briaexcavatolide P (1), was isolated from a Formosan octocoral Briareum stechei. Moreover, the same species B. stechei, collected from Okinawan waters, yielded three chlorine-containing briaranes, including two new compounds, briastecholides B (2) and C (3) as well as a known analogue, briarenol R (4). The structures of 1-4 were established using spectroscopic methods. In addition, briarane 1 demonstr ...[more]

PMID: 34833953

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