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A Molecular Study on Hepatitis E Virus (HEV) in Pigs in Bulgaria.

ABSTRACT: Information on hepatitis E virus (HEV) strains circulating in animal reservoirs in Bulgaria is currently lacking. Herein, by screening HEV seropositive sera obtained from Bulgarian swine and wild boars, viral RNA was detected at high prevalence rate (28.2%) in industrial pigs. Sequence analysis of the partial polymerase (RdRp) region revealed the highest genetic correlation with HEVs of genotype (Gt) 3 identified in French and Dutch patients. For three such strains, a 700-bp fragment of the open reading frame 2 gene was generated. On phylogenetic analysis, the Bulgarian strains clustered tightly (93.8-98.3% nt) with human and animal HEVs classified within the Gt3 subtype c.

SUBMITTER: Palombieri A

PROVIDER: S-EPMC8619608 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature

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A Molecular Study on Hepatitis E Virus (HEV) in Pigs in Bulgaria.

Palombieri Andrea A Tsachev Ilia I Sarchese Vittorio V Fruci Paola P Di Profio Federica F Pepovich Roman R Baymakova Magdalena M Marsilio Fulvio F Martella Vito V Di Martino Barbara B

Veterinary sciences 20211106 11

Information on hepatitis E virus (HEV) strains circulating in animal reservoirs in Bulgaria is currently lacking. Herein, by screening HEV seropositive sera obtained from Bulgarian swine and wild boars, viral RNA was detected at high prevalence rate (28.2%) in industrial pigs. Sequence analysis of the partial polymerase (RdRp) region revealed the highest genetic correlation with HEVs of genotype (Gt) 3 identified in French and Dutch patients. For three such strains, a 700-bp fragment of the open ...[more]

PMID: 34822640

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