The Influence of Renal Function Impairment on Kappa Free Light Chains in Cerebrospinal Fluid.

ABSTRACT:

Background

The determination of kappa free light chains (KFLC) in cerebrospinal fluid (CSF) is an upcoming biomarker for the detection of an intrathecal immunoglobulin synthesis. Since renal function impairment leads to altered serum KFLC and albumin concentrations, interpretation of KFLC in CSF may be influenced by these parameters.

Methods

In this two-center study, the influence of renal function (according to the CKD-EPI creatinine equation) on KFLC and albumin concentrations was investigated in patients with "physiological" (n = 139), "non-inflammatory" (n = 146), and "inflammatory" (n = 172) CSF profiles in respect to the KFLC index and the evaluation in quotient diagrams in reference to the hyperbolic reference range (KFLC IF).

Results

All sample groups displaye

SUBMITTER: Konen FF 

PROVIDER: S-EPMC8619759 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature