Calcium Electroporation for Keloids: A First-in-Man Phase I Study.

ABSTRACT:

Background

Keloid scarring is a pathologic proliferation of scar tissue that often causes pruritus, pain, and disfigurement. Keloids can be difficult to treat and have a high risk of recurrence. Recent studies have shown promising results in the treatment of cutaneous metastases with intralesional calcium combined with electroporation (calcium electroporation). As calcium electroporation has shown limited side effects it has advantages when treating benign keloid lesions, and on this indication we performed a phase I study.

Methods

Patients with keloids were treated with at least 1 session of calcium electroporation and followed up for 2 years. Calcium was administered intralesionally (220 mM) followed by the application of eight 100-µs pulses (400 V) using linear-array elec

SUBMITTER: Falk H 

PROVIDER: S-EPMC8619780 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature