Identification of risk factors associated with national transmission and late presentation of HIV-1, Denmark, 2009 to 2017.

ABSTRACT: BackgroundDespite availability of pre-exposure prophylaxis (PrEP), the incidence of HIV-1 in Europe remained stable the past decade. Reduction of new HIV-1 infections requires more knowledge about the profiles of high-risk transmitters and late presenters (LP).AimWe aimed to investigate risk factors associated with HIV-1 transmission clusters and late presentation with HIV-1 in Denmark.MethodsBlood samples and epidemiological information were collected from newly diagnosed HIV-1 patients between 2009 and 2017. We genotyped pol genes and performed phylogenetic analyses to identify clusters. Risk factors for clustering and LP were investigated with partial proportional odds and logistic regression. Covariates included transmission mode, HIV-1 subtype, age, origin and cluster activity.Results

SUBMITTER: van Wijhe M 

PROVIDER: S-EPMC8619873 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature