Effect of blood lipid variability on mortality in patients with type 2 diabetes: a large single-center cohort study.

ABSTRACT:

Background

Dyslipidemia is a major cardiovascular risk factor and common in diabetes patients. Most guidelines focus on optimal lipid levels, while variation of lipid profiles is far less discussed. This study aims to investigate the association of visit-to-visit variability in blood lipids with all-cause, cardiovascular, and non-cardiovascular mortality in patients with type 2 diabetes.

Methods

We identified 10,583 type 2 diabetes patients aged ≥ 30 years with follow-up ≥ 3 years and who participated in the Diabetes Care Management Program at a medical center in Taiwan. Variability in lipid profiles within 3 years after entry was calculated using coefficient of variation. Cox proportional hazard models were used to evaluate lipid variability in relation to subsequent mortal

SUBMITTER: Wang MC 

PROVIDER: S-EPMC8620132 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature