LPI-HyADBS: a hybrid framework for lncRNA-protein interaction prediction integrating feature selection and classification.

ABSTRACT:

Background

Long noncoding RNAs (lncRNAs) have dense linkages with a plethora of important cellular activities. lncRNAs exert functions by linking with corresponding RNA-binding proteins. Since experimental techniques to detect lncRNA-protein interactions (LPIs) are laborious and time-consuming, a few computational methods have been reported for LPI prediction. However, computation-based LPI identification methods have the following limitations: (1) Most methods were evaluated on a single dataset, and researchers may thus fail to measure their generalization ability. (2) The majority of methods were validated under cross validation on lncRNA-protein pairs, did not investigate the performance under other cross validations, especially for cross validation on independent lncRNAs and in

SUBMITTER: Zhou L 

PROVIDER: S-EPMC8620196 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature