A Sex-Stratified Analysis of Monocyte Phenotypes Associated with HIV Infection in Uganda.

ABSTRACT: Women with HIV may experience higher rates of non-AIDS comorbidities compared to men with HIV, but the underlying mechanisms are not well understood. We investigated sex-related differences in the effects of HIV on monocyte phenotypes within the Ugandan Study of HIV effects on the Myocardium and Atherosclerosis (mUTIMA). Of 133 participants who provided blood for flow cytometry assays, 86 (65%) were women and 91 (68%) were persons living with HIV (PLWH) on antiretroviral therapy. The median age was 57 (interquartile range, 52-63) years. PLWH exhibited a lower proportion of circulating CD14⁺CD16^- classical monocytes (66.3% vs. 75.1%; p < 0.001), and higher proportion of CD14⁺CD16⁺ inflammatory monocytes (17% vs. 11.7%; p = 0.005) com

SUBMITTER: Huaman MA 

PROVIDER: S-EPMC8620269 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature