A Physiological-Based Model for Simulating the Bioavailability and Kinetics of Sulforaphane from Broccoli Products.

ABSTRACT: There are no known physiological-based digestion models that depict glucoraphanin (GR) to sulforaphane (SR) conversion and subsequent absorption. The aim of this research was to make a physiological-based digestion model that includes SR formation, both by endogenous myrosinase and gut bacterial enzymes, and to simulate the SR bioavailability. An 18-compartment model (mouth, two stomach, seven small intestine, seven large intestine, and blood compartments) describing transit, reactions and absorption was made. The model, consisting of differential equations, was fit to data from a human intervention study using Mathwork's Simulink and Matlab software. SR urine metabolite data from participants who consumed different broccoli products were used to estimate several model parameters and valid

SUBMITTER: Shekarri Q 

PROVIDER: S-EPMC8620288 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature