Inference for case-control studies with incident and prevalent cases.

ABSTRACT: We propose and study a fully efficient method to estimate associations of an exposure with disease incidence when both, incident cases and prevalent cases, i.e., individuals who were diagnosed with the disease at some prior time point and are alive at the time of sampling, are included in a case-control study. We extend the exponential tilting model for the relationship between exposure and case status to accommodate two case groups, and correct for the survival bias in the prevalent cases through a tilting term that depends on the parametric distribution of the backward time, i.e., the time from disease diagnosis to study enrollment. We construct an empirical likelihood that also incorporates the observed backward times for prevalent cases, obtain efficient estimates of odds ratio paramet

SUBMITTER: Maziarz M 

PROVIDER: S-EPMC8620395 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature