Computational modeling of PET tracer distribution in solid tumors integrating microvasculature.

ABSTRACT:

Background

We present computational modeling of positron emission tomography radiotracer uptake with consideration of blood flow and interstitial fluid flow, performing spatiotemporally-coupled modeling of uptake and integrating the microvasculature. In our mathematical modeling, the uptake of fluorodeoxyglucose F-18 (FDG) was simulated based on the Convection-Diffusion-Reaction equation given its high accuracy and reliability in modeling of transport phenomena. In the proposed model, blood flow and interstitial flow are solved simultaneously to calculate interstitial pressure and velocity distribution inside cancer and normal tissues. As a result, the spatiotemporal distribution of the FDG tracer is calculated based on velocity and pressure distributions in both kinds of tissues.<

SUBMITTER: Fasaeiyan N 

PROVIDER: S-EPMC8620574 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature