Upregulation of TRPC5 in hippocampal excitatory synapses improves memory impairment associated with neuroinflammation in microglia knockout IL-10 mice.

ABSTRACT:

Background

Members of the transient receptor potential canonical (TRPC) protein family are widely distributed in the hippocampus of mammals and exert respective and cooperative influences on the functions of neurons. The relationship between specific TRPC subtypes and neuroinflammation is receiving increasing attention.

Methods

Using Cx3cr1^CreERIL-10^-/- transgenic mice and their littermates to study the relationship between TRPC channels and memory impairment.

Results

We demonstrated that Cx3cr1^CreERIL-10^-/- mice displayed spatial memory deficits in object location recognition (OLR) and Morris water maze (MWM) tasks. The decreased levels of TRPC4 and TRPC5 in the hippocampal regions were verified via reverse transcription po

SUBMITTER: Huo S 

PROVIDER: S-EPMC8620645 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature