Nanotechnology-Based Delivery Systems for Antimicrobial Peptides.

ABSTRACT: Antimicrobial resistance (AMR) is a significant threat to global health. The conventional antibiotic pool has been depleted, forcing the investigation of novel and alternative antimicrobial strategies. Antimicrobial peptides (AMPs) have shown potential as alternative diagnostic and therapeutic agents in biomedical applications. To date, over 3000 AMPs have been identified, but only a fraction of these have been approved for clinical trials. Their clinical applications are limited to topical application due to their systemic toxicity, susceptibility to protease degradation, short half-life, and rapid renal clearance. To circumvent these challenges and improve AMP's efficacy, different approaches such as peptide chemical modifications and the development of AMP delivery systems have been emp

SUBMITTER: Fadaka AO 

PROVIDER: S-EPMC8620809 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature