Pneumococcal Vaccines: Past Findings, Present Work, and Future Strategies.

ABSTRACT: The importance of Streptococcus pneumoniae has been well established. These bacteria can colonize infants and adults without symptoms, but in some cases can spread, invade other tissues and cause disease with high morbidity and mortality. The development of pneumococcal conjugate vaccines (PCV) caused an enormous impact in invasive pneumococcal disease and protected unvaccinated people by herd effect. However, serotype replacement is a well-known phenomenon that has occurred after the introduction of the 7-valent pneumococcal conjugate vaccine (PCV7) and has also been reported for other PCVs. Therefore, it is possible that serotype replacement will continue to occur even with higher valence formulations, but the development of serotype-independent vaccines might overcome this problem. Alte

SUBMITTER: Oliveira GS 

PROVIDER: S-EPMC8620834 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature