Uniaxial Hydroxyapatite Growth on a Self-Assembled Protein Scaffold.

ABSTRACT: Biomineralization is a crucial process whereby organisms produce mineralized tissues such as teeth for mastication, bones for support, and shells for protection. Mineralized tissues are composed of hierarchically organized hydroxyapatite crystals, with a limited capacity to regenerate when demineralized or damaged past a critical size. Thus, the development of protein-based materials that act as artificial scaffolds to guide hydroxyapatite growth is an attractive goal both for the design of ordered nanomaterials and for tissue regeneration. In particular, amelogenin, which is the main protein that scaffolds the hierarchical organization of hydroxyapatite crystals in enamel, amelogenin recombinamers, and amelogenin-derived peptide scaffolds have all been investigated for in vitro mineral gr

SUBMITTER: Danesi AL 

PROVIDER: S-EPMC8620880 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature