Nanotechnology for Topical Drug Delivery to the Anterior Segment of the Eye.

ABSTRACT: Topical drug delivery is one of the most challenging aspects of eye therapy. Eye drops are the most prevalent drug form, especially for widely distributed anterior segment eye diseases (cataracts, glaucoma, dry eye syndrome, inflammatory diseases, etc.), because they are convenient and easy to apply by patients. However, conventional drug formulations are usually characterized by short retention time in the tear film, insufficient contact with epithelium, fast elimination, and difficulties in overcoming ocular tissue barriers. Not more than 5% of the total drug dose administered in eye drops reaches the interior ocular tissues. To overcome the ocular drug delivery barriers and improve drug bioavailability, various conventional and novel drug delivery systems have been developed. Among thes

SUBMITTER: Vaneev A 

PROVIDER: S-EPMC8621153 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature