Stephan Oroszlan and the Proteolytic Processing of Retroviral Proteins: Following A Pro.

ABSTRACT: Steve Oroszlan determined the sequences at the ends of virion proteins for a number of different retroviruses. This work led to the insight that the amino-terminal amino acid of the mature viral CA protein is always proline. In this remembrance, we review Steve's work that led to this insight and show how that insight was a necessary precursor to the work we have done in the subsequent years exploring the cleavage rate determinants of viral protease processing sites and the multiple roles the amino-terminal proline of CA plays after protease cleavage liberates it from its position in a protease processing site.

SUBMITTER: Swanstrom R 

PROVIDER: S-EPMC8621278 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature