A viral insulin-like peptide is a natural competitive antagonist of the human IGF-1 receptor.

ABSTRACT:

Objective

Natural sources of molecular diversity remain of utmost importance as a reservoir of proteins and peptides with unique biological functions. We recently identified such a family of viral insulin-like peptides (VILPs). We sought to advance the chemical methods in synthesis to explore the structure-function relationship within these VILPs, and the molecular basis for differential biological activities relative to human IGF-1 and insulin.

Methods

Optimized chemical methods in synthesis were established for a set of VILPs and related analogs. These modified forms included the substitution of select VILP chains with those derived from human insulin and IGF-1. Each peptide was assessed in vitro for agonism and antagonism at the human insulin and the human insulin-like gr

SUBMITTER: Zhang F 

PROVIDER: S-EPMC8621328 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature