Curing Cats with Feline Infectious Peritonitis with an Oral Multi-Component Drug Containing GS-441524.

ABSTRACT: Feline infectious peritonitis (FIP) caused by feline coronavirus (FCoV) is a common dis-ease in cats, fatal if untreated, and no effective treatment is currently legally available. The aim of this study was to evaluate efficacy and toxicity of the multi-component drug Xraphconn® in vitro and as oral treatment in cats with spontaneous FIP by examining survival rate, development of clinical and laboratory parameters, viral loads, anti-FCoV antibodies, and adverse effects. Mass spectrometry and nuclear magnetic resonance identified GS-441524 as an active component of Xraphconn®. Eighteen cats with FIP were prospectively followed up while being treated orally for 84 days. Values of key parameters on each examination day were compared to values before treatment initiation using linear mixed-eff

SUBMITTER: Krentz D 

PROVIDER: S-EPMC8621566 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature