Gliogenic Potential of Single Pallial Radial Glial Cells in Lower Cortical Layers.

ABSTRACT: During embryonic development, progenitor cells are progressively restricted in their potential to generate different neural cells. A specific progenitor cell type, the radial glial cells, divides symmetrically and then asymmetrically to produce neurons, astrocytes, oligodendrocytes, and NG2-glia in the cerebral cortex. However, the potential of individual progenitors to form glial lineages remains poorly understood. To further investigate the cell progeny of single pallial GFAP-expressing progenitors, we used the in vivo genetic lineage-tracing method, the UbC-(GFAP-PB)-StarTrack. After targeting those progenitors in embryonic mice brains, we tracked their adult glial progeny in lower cortical layers. Clonal analyses revealed the presence of clones containing sibling cells of either a glia

SUBMITTER: Ojalvo-Sanz AC 

PROVIDER: S-EPMC8621618 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature