Establishment and validation of an individualized macrophage-related gene signature to predict overall survival in patients with triple negative breast cancer.

ABSTRACT:

Background

Recently, researchers have classified highly heterogeneous triple negative breast cancer (TNBC) into different subtypes from different perspectives and investigated the characteristics of different subtypes to pursue individualized treatment. With the increase of immunotherapy and its preliminary application in TNBC treatment, the value of immune-related strategies in the treatment of TNBC has been initially reflected. Based thereon, this study plans to classify and further explore TNBC from the perspective of immune cell infiltration.

Method

The fractions of immune cells of TNBC patients were assessed by six immune component analysis methods in The Cancer Genome Atlas (TCGA) database. Hub genes significantly related to poor prognosis were verified by weighted gen

SUBMITTER: Su P 

PROVIDER: S-EPMC8621725 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature