Potential of Vitamin D Food Fortification in Prevention of Cancer Deaths-A Modeling Study.

ABSTRACT: Meta-analyses of randomized controlled trials (RCTs) have estimated a 13% reduction of cancer mortality by vitamin D supplementation among older adults. We evaluated if and to what extent similar effects might be expected from vitamin D fortification of foods. We reviewed the literature on RCTs assessing the impact of vitamin D supplementation on cancer mortality, on increases of vitamin D levels by either supplementation or food fortification, and on costs of supplementation or fortification. Then, we derived expected effects on total cancer mortality and related costs and savings from potential implementation of vitamin D food fortification in Germany and compared the results to those for supplementation. In RCTs with vitamin D supplementation in average doses of 820-2000 IU per day, ser

SUBMITTER: Niedermaier T 

PROVIDER: S-EPMC8621821 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature