Some novel hybrid quinazoline-based heterocycles as potent cytotoxic agents.

ABSTRACT:

Background and purpose

In this study, some new cytotoxic hybrid structures were synthesized by combining pyrazolinone and imidazolinone rings with quinazoline pharmacophores.

Experimental approach

The benzoxazinone, pyrazolo-quinazoline fused ring, and imidazolinone anchored quinazoline derivatives were synthesized by simple ring-opening, ring expansion, and ring closure strategies from oxazolones. The molecular docking studies of the final derivatives were accomplished on the epidermal growth factor receptor enzyme. The cytotoxic effect of the final compounds on the MCF-7 cell line was evaluated by MTT assay.

Findings/results

The docking results confirmed the optimized electrostatic, H-bonding, and hydrophobic interactions of structures with the key residues of the a

SUBMITTER: Malekzadeh M 

PROVIDER: S-EPMC8621847 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature