Combined Therapy with microRNA-Expressing Salmonella and Irradiation in Melanoma.

ABSTRACT: Anticancer treatment strategies using bacteria as a vector are currently expanding with the development of anticancer drugs. Here, we present a research strategy to develop anticancer drugs using bacteria that contain miRNAs. We also present a strategy for the development of novel bacterial anticancer drugs in combination with radiation. Salmonella strains expressing miRNA were produced by modifying the miRNA expression vector encoding INHA, a radiation-resistant gene developed previously. The anticancer effect of INHA was confirmed using skin cancer cell lines. We also tested a combination strategy comprising bacteria and radiation for its anticancer efficacy against radiation-resistant mouse melanoma to increase the efficacy of radiation therapy as a novel strategy. The recombinan

SUBMITTER: Yoon W 

PROVIDER: S-EPMC8621892 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature