The Challenging Melanoma Landscape: From Early Drug Discovery to Clinical Approval.

ABSTRACT: Melanoma is recognized as the most dangerous type of skin cancer, with high mortality and resistance to currently used treatments. To overcome the limitations of the available therapeutic options, the discovery and development of new, more effective, and safer therapies is required. In this review, the different research steps involved in the process of antimelanoma drug evaluation and selection are explored, including information regarding in silico, in vitro, and in vivo experiments, as well as clinical trial phases. Details are given about the most used cell lines and assays to perform both two- and three-dimensional in vitro screening of drug candidates towards melanoma. For in vivo studies, murine models are, undoubtedly, the most widely used for assessing the therapeutic potential of

SUBMITTER: Matias M 

PROVIDER: S-EPMC8621991 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature