Epigenetic profiling of social communication trajectories and co-occurring mental health problems: a prospective, methylome-wide association study.

ABSTRACT: While previous studies suggest that both genetic and environmental factors play an important role in the development of autism-related traits, little is known about potential biological mechanisms underlying these associations. Using data from the Avon Longitudinal Study of Parents and Children (ALSPAC), we examined prospective associations between DNA methylation (DNAm: n_birth = 804, n_{age 7} = 877) and trajectories of social communication deficits at age 8-17 years. Methylomic variation at three loci across the genome (false discovery rate = 0.048) differentiated children following high (n = 80) versus low (n = 724) trajectories of social communication deficits. This differential DNAm was specific to the neonatal period and not observed at

SUBMITTER: Rijlaarsdam J 

PROVIDER: S-EPMC8622455 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature