Synthesis of Functional Building Blocks for Type III-B Rotaxane Dendrimer.

ABSTRACT: Second-generation type III-B rotaxane dendrons, equipped with succinimide and acetylene functional groups, were synthesized successfully and characterized by NMR spectroscopy and mass spectrometry. A cell viability study of a dendron with a normal cell line of L929 fibroblast cells revealed no obvious cytotoxicity at a range of 5 to 100 μM. The nontoxic properties of the sophisticated rotaxane dendron building blocks provided a choice of bio-compatible macromolecular machines that could be potentially developed into polymeric materials.

SUBMITTER: Kwan CS 

PROVIDER: S-EPMC8622516 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature