Pharmaco-Metabolomics of Inhaled Corticosteroid Response in Individuals with Asthma.

ABSTRACT: Metabolomic indicators of asthma treatment responses have yet to be identified. In this study, we aimed to uncover plasma metabolomic profiles associated with asthma exacerbations while on inhaled corticosteroid (ICS) treatment. We determined whether these profiles change with age from adolescence to adulthood. We utilized data from 170 individuals with asthma on ICS from the Mass General Brigham Biobank to identify plasma metabolites associated with asthma exacerbations while on ICS and examined potential effect modification of metabolite-exacerbation associations by age. We used liquid chromatography-high-resolution mass spectrometry-based metabolomic profiling. Sex-stratified analyses were also performed for the significant associations. The age range of the participating individuals wa

SUBMITTER: Kachroo P 

PROVIDER: S-EPMC8622526 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature