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Structural Studies of β-Diketones and Their Implications on Biological Effects.

ABSTRACT: The paper briefly summarizes methods to determine the structure of β-diketones with emphasis on NMR methods. Density functional calculations are also briefly treated. Emphasis is on the tautomeric equilibria of β-diketones in relation to biological effects. Relevant physical parameters such as acidity and solubility are treated. A series of biologically active molecules are treated with respect to structure (tautomerism). Characteristic molecules or groups of molecules are usnic acids, tetramic and tetronic acids, o-hydroxydibenzoylmethanes, curcumines, lupulones, and hyperforines.

SUBMITTER: Hansen PE

PROVIDER: S-EPMC8622542 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature

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Structural Studies of β-Diketones and Their Implications on Biological Effects.

Hansen Poul Erik PE

Pharmaceuticals (Basel, Switzerland) 20211120 11

The paper briefly summarizes methods to determine the structure of β-diketones with emphasis on NMR methods. Density functional calculations are also briefly treated. Emphasis is on the tautomeric equilibria of β-diketones in relation to biological effects. Relevant physical parameters such as acidity and solubility are treated. A series of biologically active molecules are treated with respect to structure (tautomerism). Characteristic molecules or groups of molecules are usnic acids, tetramic ...[more]

PMID: 34832971

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