Peptide-Based Vaccines for Neurodegenerative Diseases: Recent Endeavors and Future Perspectives.

ABSTRACT: The development of peptide-based vaccines for treating human neurodegenerative diseases has been the eventual aim of many research endeavors, although no active immunotherapies have been approved for clinical use till now. A typical example of such endeavors is the effort to develop vaccines for Alzheimer's disease based on the beta-amyloid peptide, which continues to be intensively investigated despite previous setbacks. In this paper, recent developments in peptide-based vaccines which target beta-amyloid as well as tau protein and α-synuclein are presented. Particular focus has been directed toward peptide epitopes and formulation systems selected/developed and employed to enhance vaccine efficacy and safety. Results from both, human clinical trials and animal preclinical studies conduc

SUBMITTER: Vassilakopoulou V 

PROVIDER: S-EPMC8622585 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature