Topical Delivery of Niacinamide to Skin Using Hybrid Nanogels Enhances Photoprotection Effect.

ABSTRACT: Niacinamide (NIA) has been widely used in halting the features of ageing by acting as an antioxidant and preventing dehydration. NIA's physicochemical properties suggest difficulties in surpassing the barrier imposed by the stratum corneum layer to reach the target in the skin. To improve cutaneous delivery of NIA, a hybrid nanogel was designed using carrageenan and polyvinylpyrrolidone polymers combined with jojoba oil as a permeation enhancer. Three different types of transethosomes were prepared by the thin-film hydration method, made distinct by the presence of either an edge activator or a permeation enhancer, to allow for a controlled delivery of NIA. Formulations were characterized by measurements of size, polydispersity index, zeta potential, encapsulation efficiency, and loading c

SUBMITTER: Basto R 

PROVIDER: S-EPMC8622650 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature