Lasting Changes to Circulating Leukocytes in People with Mild SARS-CoV-2 Infections.

ABSTRACT: Survivors of severe SARS-CoV-2 infections frequently suffer from a range of post-infection sequelae. Whether survivors of mild or asymptomatic infections can expect any long-term health consequences is not yet known. Herein we investigated lasting changes to soluble inflammatory factors and cellular immune phenotype and function in individuals who had recovered from mild SARS-CoV-2 infections (n = 22), compared to those that had recovered from other mild respiratory infections (n = 11). Individuals who had experienced mild SARS-CoV-2 infections had elevated levels of C-reactive protein 1-3 months after symptom onset, and changes in phenotype and function of circulating T-cells that were not apparent in individuals 6-9 months post-symptom onset. Markers of monocyte activation, and expressio

SUBMITTER: Kennedy AE 

PROVIDER: S-EPMC8622816 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature